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doi: 10.1172/JCI114559 89 BosiaASpangenbergPLscheWAresePTillU

The advantage of this data evaluation is that the reciprocal coefficients 1/ 1 and 1/ 2 can be interpreted as apparent rate constants k ox app and k red app for the oxidative and reductive half-reaction, respectively

Delayed processing or inadequate thiol stabilization can generate GSSG after collection, so interpretation requires standardized handling and adequate analytical performance at the lower end of the GSSG range (Tomin et al., 2020

Outcomes differ by dose, route (including intravenous glutathione), cofactors like ascorbic acid, baseline skin pigmentation, and dark spots