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Because NF-B is an activator of many pro-inflammatory cytokines, including IL-6 (32), this could contribute to increased inflammation and the cytokine storms observed in COVID-19, and be a significant basis of pathogenic effects associated with SCoV2 infection of various tissues, including the lung, gastrointestinal tract and cardiovascular system

Whether DAM are neuroprotective or neurotoxic likely depends on the disease context and state, warranting further investigation