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Notably, one promising avenue involves leveraging the astrocytic urea cycle to enhance neuroprotection and facilitate a liver-like clearance mechanism in the brain, offering potential strategies for mitigating neurodegenerative processes 59,73

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Ser3, critical for acylation-mediated, receptor activation, is preserved in nearly all species except for bullfrogs, where it is replaced by threonine (Thr3) (Kaiya et al., 2001)

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