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Doses become larger than intended, increasing the risk of side effects and accelerating through your dose escalation faster than planned

And with all this evidence, I believe none of these studies controlled for genetic causes, for example, of hair loss

However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)

Using flux analysis after feeding [ 35 S]-sulfate, Speiser et al