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Moreover, IL-17A and TNF- act synergistically to drive a marked upregulation of the chemokines CCL20 and CXCL8 sustaining leukocyte recruitment [4, 84]

In the tumor microenvironment, infiltrating CD8+ T cells produce IFN- which drives the expression of PD-L1 on lymphatic endothelial cells (LECs) (94)

Its primary role is to transport long-chain fatty acids into the mitochondria of muscle cells for oxidation, producing energy