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Future advances will depend on innovative drug delivery systems and integration with complementary proteostasis-modulating strategies

It may require significant dietary changes, long-term medication, and in some cases, hospitalization for malnutrition or dehydration

The FDA approved tirzepatide in May 2022 under the brand name Mounjaro for type 2 diabetes management, and in November 2023 under the brand name Zepbound for chronic weight management in adults meeting specific BMI criteria

O'Regan RM, Cisneros A, England GM, MacGregor JI, Muenzner HD, Assikis VJ, Bilimoria MM, Piette M, Dragan YP, Pitot HC, Chatterton R, Jordan VC: Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth