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For some faces, this can lead to a more streamlined jawline or greater definition of the cheekbones, whereas for others it can be associated with loss of elasticity, which results in a sagging appearance

Last Published 01.01.2026 Effective Date: 01.01.2026 This policy addresses extracorporeal shock wave therapy (ESWT) for musculoskeletal and soft tissue conditions

This leads to neuroinflammation, vascular occlusion, mitochondrial dysfunction, and the aggregation of pathognomonic proteins, which, in turn, trigger neurodegeneration in the cerebral cortex for AD and the substantia nigra for PD (illustrated in Fig