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MOTS-c Primary focus: Mitochondrial metabolism Insulin sensitivity Metabolic aging in women MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is encoded in mitochondrial DNA not the nuclear genome and functions as a mitochondrial-derived peptide that communicates metabolic stress signals systemically

Intravenous delivery results in immediate full-concentration exposure and typically the shortest apparent half-life because peak plasma levels degrade the fastest

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