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Taken together, these biochemical results suggest that ultraviolet irradiation of the skin causes changes compatible with aging that manifest as a reduction in the content of pro-collagen type 1, elastin and sulfated GAGs, as well as an increase in MMP1 activity, and the CG treatment reverses these changes by increasing the levels of these extracellular matrix components, except for MMP1 activity, which can be attributed to its rejuvenating effect

Patients with compromised immune systems or chronic inflammatory conditions frequently achieve better outcomes with TB-500's broader anti-inflammatory effects

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Notably, keystone taxa that became more prominent over time were associated with anti-adipogenesis, improved insulin sensitivity, and reduced metabolic disease risk