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Although GLP-1 receptor agonists have demonstrated effectiveness in reducing weight loss and risks for other chronic diseases, questions remain over whether the benefits outweigh the harms of the drugs, including their cost-effectiveness and economic impact, Hannah Moll, a PhD candidate from the department of epidemiology at the University of Zurich in Switzerland, and colleagues, wrote in eClinicalMedicine

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That said, inconsistencies in dosing can lead to underwhelming results or mild systemic side effects such as headaches or nasal irritationparticularly in compounded or off-label versions