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The innate immune cells are activated in COVID-19, and the mast cells play an important role in this regard, releasing histamine, cytokines, and chemokines, raising the inflammatory reactions, which makes mast activation a major contributor to neuroinflammation and neurodegeneration (Kempuraj et al

Phentermine/topiramate (PHEN/TPM) Weight loss trials PHEN/TPM combines an amphetamine analogue with a gamma-aminobutyric acid (GABA) agonist, glutamate antagonist, and carbonic anhydrase inhibitor

They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

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