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(1) Systemic entry and uptake: Tyramine escapes normal intestinal and hepatic metabolism, enters the circulation, and is transported into sympathetic nerve terminals via the norepinephrine transporter (NET)

[25], with permission from Oxford University Press

The estimates above are based on trial completion dates and standard regulatory timelines

The C5 domain of nocardicin NRPS (NocB) not only fulfills its canonical function by forming the corresponding amide bond in the growing peptide chain, but also mediates cyclization of the beta lactam ring 29