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6 El uso de un objetivo de HbA1c de 6.5% para el diagnstico de diabetes y como meta teraputica se basa en estudios que siguen vigentes ( United Kingdom Prospective Diabetes Study 1998), donde se demostr que la diabetes mellitus tipo 2 adecuadamente controlada reduce la incidencia de complicaciones crnicas atribuidas a la hiperglucemia crnica (retinopata, nefropata y neuropata)

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2) Prolia (denosumab) Ranked as Amgens second-highest grossing drug in 2022, Prolia brought in a revenue of $3.63 billion

In Figures 5C and D , Sema bolus and PNP-1-10-0.05 Sema-1.8 mg/mL hydrogel both induced reductions in blood glucose, but the hydrogel formulation ( Figure 5D ) exhibited more durable glycemic control over time, with lower inter-animal variability