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As awareness grows, so does the opportunity to help patients, clinicians, and healthcare systems recognize the value of the mouth as a window into the body

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A study of the effects of formononetin on fluorescein isothiocyanate-induced AD murine model (10 mg/kg) and the same human keratinocyte cell line (10 M) confirmed reduced TSLP levels and upregulated TNF- induced protein 3 (TNFAIP3/A20) by G protein-coupled estrogen receptor (GPER) activation [124]

FEBS Lett 529:93101 Taylor JM, Ali U, Iannello RC, Hertzog P, Crack PJ (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death