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[34] [108] [109] [110] [3] GLP-1 receptor agonists like semaglutide may indirectly positively influence testosterone levels via weight loss in obese men, but this is not a direct interaction and does not indicate adverse effects

Chronic low-grade inflammation causes fatigue that mimics depression, often described as feeling heavy, sluggish, or unmotivated

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BMC Cardiovasc Disord 25(1):329 Lian J, Xu Y, Shi J, Liu P, Hua Y, Zhang C, Ren T, Su G, Cheng S, Nie Z, Jia T (2024) Acteoside and isoacteoside alleviate renal dysfunction and inflammation in lipopolysaccharide-induced acute kidney injuries through inhibition of NF-kappaB signaling pathway