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Furthermore, although the introduction of chemiluminescent probes to detect microbial oxygen metabolites allows for rapid estimation of the minimum inhibitory concentration (MIC), this method suffers from poor consistency in detection results [16]

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Several potential associations have been given, excessive oxidative stress, respiratory chain abnormalities and imbalances in mitochondrial dynamics leading to mitochondrial dysfunction, as well as the fact that both endogenous and exogenous NO can induce apoptosis through mitochondria-dependent mechanisms (144)

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