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What the study actually showed: Using the Broad Institutes Connectivity Map database (which catalogs gene expression changes in human cell lines exposed to ~1,300 compounds), the researchers identified that GHK treatment shifted the expression of approximately 31% of genes by more than 50% in either direction

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doi: 10.1016/j.peptides.2019.170171

As discussed above, unlike Y37 rAmy , P37 Cagri does not interact directly with RAMP1 or RAMP3, which likely decreases the stability of the ECD interface, leading to increased dynamics relative to the rAmy-bound AMY 1 R and rAmy-bound AMY 3 R (Fig