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Semaglutide is contraindicated if you have had medullary thyroid carcinoma (MTC) or an endocrine system condition known as Multiple Endocrine Neoplasia Syndrome type 2 (MEN 2), or if you have had a serious allergic reaction to Semaglutide, or if you are pregnant or breastfeeding
The recent data from the STEER real-world study of evidence gathered from actual patient experiences at the European Society of Cardiology (ESC) Congress 2025 in Madrid, Spain, revealed that semaglutide 2.4 mg showed a significant reduction in the risk of heart attack, stroke or death from any cause, in people with overweight or obesity and cardiovascular disease (CVD)
The compound triggers a process the downstream benefits depend on how much senescent cell burden existed, how efficiently the immune system clears debris, and how effectively tissues regenerate
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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