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The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection (20)

Nitrogen containing compounds Nitrogen containing secondary metabolites, especially derived from medicinal plants exhibits a potent anti-inflammatory and immune regulating properties against UC [123]