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Further, a placebo-controlled trial in 152 elderly adults (aged 70-80 years) with mild cognitive impairment reported that B vitamin supplementation (50 mg/day of vitamin B 6 , 5 mg/day of folic acid, and 0.4 mg/day of vitamin B 12 ) for one year did not improve performance on a similar test of verbal fluency (136)

Hospital practitioners and pharmacists compounding or preparing therapeutic goods for treatment at public hospitals are generally exempt, and specific exemptions apply to persons or institutions handling therapeutic goods in the context of approved clinical trials or for immediate, localised administration

Supplementation of some vitamins at higher doses level can cause toxicity

At the same time, most risks can be minimized when treatment is done by experienced professionals