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Originally investigated as a potential treatment for Alzheimers disease, Dihexa demonstrates potent ability to enhance synaptic connections and promote neuronal survival through modulation of hepatocyte growth factor (HGF) and its receptor c-Met, which play crucial roles in brain development and neuronal health

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PMCID: PMC9032824

These evolutionary studies reveal that fewer clones of cancer cells from the primary tumor site can form metastases in distant organs compared to TDLNs, which might be attributed to the different selective pressures and microenvironments in these organs, such as the varying metabolites in distant organs (161, 162)