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GCH1 can remodel lipid environment in plasma membranes to promote the accumulation of reduced CoQ10 and deplete FUPAs, ultimately increase the sensitivity to ferroptosis (Kraft et al., 2020)

Ceci permet de lutter contre les peroxydes organiques : 2 GSH + R-OOH GS-SG + ROH + H 2 O ce qui forme finalement un pont cystine, un alcool et une molcule d'eau

This in-clinic treatment helps correct iron deficiency and related fatigue by replenishing iron directly into the bloodstream

Malignant transformation can occur but is also rare ( Axial T1-weighted image in the same patient shows a bright lesion with an internal septation