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Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E

Comment: Several commenters expressed concerns with the methodology CMS uses to identify topped-out measures in specialty measure sets and MVPs as at risk and, therefore, eligible for the defined topped-out measure benchmark

Studies have shown that TCM formulas, botanical drugs, and their active metabolites can significantly enhance the balance of the gut microbiota, correcting lipid and glucose metabolism disorders, and effectively reducing chronic inflammation and oxidative stress

Overall, IGF-1R mAbs hold promise for prostatic cancer treatment, but further research is needed to optimize their efficacy and safety, particularly in combination therapies, while exploring new mAbs with improved targeting strategies