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Circulating SHBG levels are inversely correlated with markers of non-alcoholic fatty liver disease (NAFLD) and insulin resistance ( e.g ., metformin) have been shown to elevate SHBG levels in women with PCOS, establishing SHBG as a reliable biomarker for insulin resistance ( Combined oral contraceptives (COCs) are first-line treatments for PCOS, effectively lowering androgen levels and restoring menstrual regularity

Nucleic Acids Res 48 , 28532865 (2020)