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Interestingly, the activation of AMPK also leads to an increase in NAD + levels ( The circadian rhythm system, CLOCK gene mechanism and metabolic pathways are intertwined by neural circuits which transmit the environmental signals to peripheral organs through hormones, chemokines and neuropeptides (Mazzoccoli et al., 2012)

Recently, inhibition of phosphodiesterase 5 (PDE5) and HDAC has been suggested as a potent novel therapeutic approach for AD (Rabal et al., 2016

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