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A real-life example: Jennifer (not her real name) found out she was pregnant at 5 weeks while taking semaglutide
A phase Ib trial with a 4-week subcutaneous administration of either 10 mg or 15 mg tirzepatide once weekly in subjects with T2D led to a significant reduction in fasting plasma glucose concentrations (LSM difference [95% CI]: 49.12 mg/dl [78.14, 20.12] and 43.15 mg/dl [73.06, 13.21], respectively) and to reductions in body weight (LSM difference [95% CI]: 2.62 kg [3.79, 1.45] and 2.07 kg [3.25, 0.88], respectively
This shortage opened a temporary but lucrative opportunity for compounding pharmacies, which the Federal Food, Drug, and Cosmetic Act permits to produce copycat versions of branded drugs during officially declared shortages
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