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For example, combinations of GLP-1/glucagon RA achieve more liver fat content reduction in people with MASLD compared to GLP-1 RA alone despite similar WL, likely due to the direct effect of glucagon on hepatic lipid oxidation [79]

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Any combination protocol would need to account for this redundancy and the potential for additive GI side effects

Durante la hipoglucemia inducida, semaglutida no alter las respuestas contrarreguladoras a mayores niveles de glucagn y no deterior la disminucin del pptido C en pacientes con diabetes mellitus tipo 2 en comparacin con placebo