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Notably, some preclinical data support that the benefits of semaglutide on hepatic steatosis may not be entirely dependent on weight reduction

Semaglutide improved outcomes in both the heart failure with reduced EF group (MACE HR 0.65) and the heart failure with preserved EF group (MACE HR 0.69)

However, the principal factor of cerebrovascular diseases is the BBB breakdown, characterized by blood component infiltration, aberrant transport, and clearance of molecules into the central nervous system (CNS) (Yang and Rosenberg, 2011

The reduction in cell viability between MB and untreated controls was not statistically significant (Kruskal-Wallis test) at the three time points evaluated