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Research suggests DSIP modulates GABAergic and glutamatergic neurotransmission, interacts with the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol and ACTH levels, and may influence circadian rhythm regulation through effects on melatonin and serotonin pathways

In addition, in the New Zealand obese (NZO) mice, in contrast to GLP-1, the GLP-1 and E2 conjugate significantly decreased food intake and prevented obesity, thus preventing T2D 17

This helps to maintain your skin's elasticity and keep it hydrated

However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort