As a triple agonist, retatrutide stimulates three potent hormone receptors that control energy balance, metabolism, and weight: Glucagon-Like Peptide-1, or GLP-1: Diminishes appetite Delays the emptying of the stomach Enhances blood sugar regulation Glucose-Dependent Insulinotropic Polypeptide, or GIP: Improves the response to insulin Promotes metabolic adaptability Enhances the use of nutrients The glucagon receptor: Raises energy costs Encourages the burning of fat Aids in the mobilization of fat reserves Compared to single-agonist or dual-agonist therapies, the synergistic effect of these triple agonists results in more effective and long-lasting weight loss
How they work together Vitamin C helps maintain glutathione in its reduced, active state, while glutathione provides direct intracellular antioxidant activity
Studies suggest that people whose biological age exceeds their actual age face a higher risk of disease and early death
DOI: 10.1172/JCI116186 [6] Coskun, T., Sloop, K.W., Loghin, C., et al
