Warnings and precautions include acute pancreatitis, acute gallbladder disease, acute kidney injury due to volume depletion, hypoglycemia with concomitant insulin or insulin secretagogues, severe gastrointestinal adverse reactions, hypersensitivity reactions, and pulmonary aspiration during general anesthesia or deep sedation
This is revealing, as abnormalities in circadian rhythms are considered to play a potential underlying role in bipolar disorder, as many genes associated with bipolar disorder including CLOCK , PER3 and BMAL1 are regulated in a circadian manner [70,71,72]
If side effects become intolerable despite optimisation strategies, dose reduction or treatment discontinuation may be necessary
Problem: hair thinning during weight loss Rapid weight loss from any cause, including GLP-1 therapy, can trigger telogen effluvium, a temporary condition where hair shifts into its resting phase and falls out more than usual