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Managing Side Effects During Dose Escalation Mild nausea, reduced appetite, and changes in bowel habits are common in the first few days after a dose increase and typically resolve within 35 days

At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off

Gene aliases : GLP-1, GLP1, GLP2, GRPP Gene ID : (Human) 2641 Gene symbol : GCG Protein Aliases : glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, GRPP, OXM, OXY, GLP-1, Incretin hormone, GLP-1(7-37), GLP-1(7-36), GLP-2, GLP1/2, Glucagon like peptide 1, MGC138331, incretin, preproglucagon UniProt ID (Human) P01275

A plaques have also been associated with neuroinflammation (Leng and Edison, 2020