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Additionally, GLP-1RA reduced the production of various of AGEs-induced catabolic factors (MMP1, MMP3, MMP13, ADAMTS4 and ADAMTS5), preventing matrix degeneration, while promoting anabolism

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How GLP-1 Medications Affect Blood Vessel Function and Clotting GLP-1 receptor agonists work primarily in the pancreas and gastrointestinal tract to regulate blood sugar and appetite, but they also activate GLP-1 receptors on blood vessel walls