J Physiol Pharmacol 65(3):349357 Cui X, Zhao X, Wang Y, Yang Y, Zhang H (2020) Glucagonlike peptide1 analogue exendin4 modulates serotonin transporter expression in intestinal epithelial cells
Medications for Nausea and Vomiting (OTC: Over-the-Counter) Meclizine (Bonine) OTC at low doses (25mg), prescription for higher doses (50 mg or more) Dimenhydrinate (Dramamine) OTC Nauzene-OTC Pepto-Bismol-OTC Dramanine-OTC Emetrol OTC Ondansetron (Zofran) by prescription (check with your doctor, it can cause constipation, a GLP-1 side effect) Metoclopramide (Reglan for GERD) by prescription (check with your doctor, it is used to treat gastroparesis which means it increases gastric emptying
Several methods are introduced to increase the half-life of GLP-1 including: (i) modifying peptides to make them resistant to cleavage by DPP-4, such as exenatide twice daily and lixisenatide, (ii) attaching free fatty acid side chains to liraglutide and semaglutide, which enhances their binding to plasma albumin thereby preventing renal filtration of GLP-1 and prolonging their action in vivo [36, 37], (iii) conjugation of albumin or the Fc fragment of IgG to GLP-1 molecule is used in albiglutide and dulaglutide [37, 38], (iv) development of modified nanoparticles for the controlled release of exenatide-LAR (long-acting release) that provide prolonged release of the peptide [39], and finally, (v) chemical permeation enhancers such as sodium salcaprozate (SNAC) could be utilized to overcome the low permeability and high enzymatic degradation of the gastrointestinal tract of GLP-1 analog that is administrated orally such as semaglutide [40]
PlexusDx provides semaglutide injection therapy through licensed compounding pharmacies with dosing tailored to your individual response
