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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

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Medication Administration If prescribed, semaglutide may be administered as a once-weekly injection or taken orally, depending on the formulation selected

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Most experts recommend 0.7 to 1 gram per pound of body weight daily

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