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In accordance with the conclusions from the trial [21], the modelled PK profiles were similar for subjects with or without upper GI disease (Fig

Patients should be counselled that a modest but consistent downward trend in weight during the first month is a positive indicator, and that the full benefit of treatment is expected to emerge over a longer treatment course

In animal studies, SGLT2 inhibitors were generally safe during the first trimester but exposure during postnatal day 21 to 90 in juvenile rats, a period coinciding with the late second and third trimester of human renal development, caused dilatation of the renal pelvis and tubules

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