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Despite being short-lived, these fish display a wide range of age-dependent transformations after the onset of sexual maturation, including telomere shortening 15,16 , tumorigenesis 12 , neurodegeneration 17,18 , decreased capacity of tissue regeneration 19 , increased markers of cellular senescence in heart, brain and skin 17,20,21 , loss of microbial richness in the intestine 22 , decline in sperm quality 23 and decline in the diversity of the B cell antibody repertoire 24

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