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10.1073/pnas.0307659101 194 SolonM.GeN.HambroS.HallerS.JiangJ.BacaM.et al (2024)

Cell (2020) 180:3349.e22

FIGURE 7 Collectively, these results highlight the anti-apoptotic effects of GO@GSH-FA in SH-SY5Y cells subjected to OGD/R, demonstrating its potential as a therapeutic agent for mitigating apoptosis in cerebral Ischemia-Reperfusion injury

The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis