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Pharmaceutical companies are intensifying R&D investments to optimize oral GLP-1 efficacy and expand indication approvals

This suggests that microbial and metabolic disruptions become increasingly entrenched over time, highlighting the urgent need for early, targeted interventions using specialized prebiotic fibers to halt the progression of dysbiosis and restore SCFA production before permanent neurological damage occurs

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily prescribed for type 2 diabetes management

Animal experiments All procedures performed in rats were approved by the Institutional Animal Care and Use Committee at the Seattle Childrens Research Institute (IACUC00064) and were in accordance with the National Institutes of Health (NIH) Guide for Care and Use of Laboratory Animals