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IGF-1-LR3 IGF-1-LR3 (Long Arg3 IGF-1) is a modified variant of Insulin-like Growth Factor-1 with a much longer half-life and significantly reduced binding to binding proteins

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Interestingly, each of the clusters comprises one of the well-characterized thiamine transporters: SLC19A3 shares the cluster 1a with thiamine/ThDP-dependent proteins of higher expression, while SLC19A2 shares the cluster 1b with thiamine/ThDP-dependent proteins of lower expression

In line with these observations in rodents, human genetic studies published in the early 2000s identified MC4R mutations as the most common monogenic cause of obesity, affecting up to 6% of individuals with severe obesity (36)