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Tirzepatide Pathway (Dual Agonist): Gut Mimics GLP-1 + GIP Delays Gastric Emptying + Improves Insulin Sensitivity Result: Reduced Appetite + Balanced Blood Sugar Steady Weight Loss Retatrutide Pathway (Triple Agonist): Gut Mimics GLP-1 + GIP + Glucagon Delays Gastric Emptying + Improves Insulin Sensitivity + Stimulates Liver Result: Reduced Appetite + Increased Lipolysis (Fat Burning) + High Energy Expenditure Aggressive Weight Loss Why Retatrutide Might Be "Better" Experimental findings show that Retatrutide addresses the primary limitation of all previous weight loss peptides: adaptive thermogenesis

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doi:10.3389/fragi.2023.1292053 Gasek NS, Kuchel GA, Kirkland JL, Xu M