LPS has been shown to have variable bioactivity, with hexa-acylated LPS inducing inflammation but not penta-acylated LPS ( The atherosclerotic process begins with a fatty streak and progresses to plaque rupture and acute atherothrombosis, which can lead to critical clinical events including stroke or myocardial infarction (Vatanen et al., 2016)
Napoletano F, Gibert B, Yacobi-Sharon K, Vincent S, Favrot C, Mehlen P, et al
Chronic GI problems, pancreatitis, kidney injury, gallbladder disease, hormonal issues, and unresolved safety questions mean long-term monitoring is essential
Interestingly, these patients also had decreased mortality compared to patients who died without dementia, demonstrating a possible lifespan benefit with GLP1RA treatment compared to other anti-diabetic drugs [58]