77,78,83 Depletion of ALDH1L2 markedly decreases the NADPH/NADP + and GSH/GSSG ratios, reduces the circulating tumor cells in blood and alleviates the metastatic burden
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Ferroptosis can be inhibited to a certain extent by necroptosis inhibitors [24]
NADPH is the reducing power required for the synthesis of fatty acids, sterols, nucleotides and non-essential amino acids (1, 2)