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Of course, more studies are needed to confirm or deny this possibility, but current research is encouraging

10.1016/j.drup.2015.02.002 188 van VlietE

The additional author of the study, An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life, was Bin Zhou of TSRI

GPR43 activation by SCFAs reduces intracellular ATP depletion and reactive oxygen species (ROS) production, which are critical for NLRP3 assembly (132, 133)