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The creatine supplementation also promoted energy reserve in the muscle of spotted seabass by increasing ATP concentrations and creatine kinase activity, while inhibiting anaerobic glycolysis by reducing the activities of lactate dehydrogenase and pyruvate kinase [38]

This enables the uptake of PepT1 transporter substrates to be coupled with the influx of protons back into the enterocytes (Adibi 1997)

PMID 16307756

Therapeutic applications include: cognitive function, protection associated with memory and neurodegenerative disorders, arthritis, inflammatory and auto-immune disorders, cardiac health, inflammatory bowel disease, liver, kidney and pancreas health as well as muscle preservation