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Site rotation: As discussed previously, systematic rotation is crucial for preventing cumulative tissue damage

The concurrent engagement of all three receptors is hypothesised to produce complementary metabolic effects in pre-clinical models: GLP-1R activation is associated with glucose regulation and appetite modulation, GIPR activation with potentiation of GLP-1mediated responses, and GcgR activation with energy expenditure and hepatic lipid metabolism in laboratory settings

(2014) Fructose-1,6-bisphosphatase opposes renal carcinoma progression, Nature , 513 , 251-255, doi: Anderton, B., Camarda, R., Balakrishnan, S., Balakrishnan, A., Kohnz, R

Table 5 Outcome assessment and conclusions