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SCFAs mediate some of their biological effects via the G protein-coupled receptors FFA2 and FFA3, and there has been increased interest recently in the beneficial role of FFA2 in gastrointestinal physiology and immune function, as well as in energy and glucose homeostasis

The anti-cancer activity of coumarin and its derivatives has been described to be directed against numerous types of cancers such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, and malignant melanoma [60, 61]