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Using a similar process, the risk of bias for intervention trials included in the review omitting the case report [54] was assessed using the criteria set out in the Cochrane Collaboration Handbook [55]

Furthermore, the endogenous peptide Agouti-related peptide (AgRP), which is an inverse agonist on MC4R and a competitive antagonist or ERK-biased agonist on MC3R, is known to increase food intake and body weight (30, 31)

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