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This is a normal physiological response: as body weight decreases, the amount of thyroid hormone needed may shift slightly

The PVN coordinates autonomic and neuroendocrine activities for regulation of metabolism, and contains pre-autonomic neurons that control pancreatic SNS activity and insulin secretion 50

Data from only three groups (vehicle, AMG 133 0.25 mg kg 1 and AMG 133 0.75 mg kg 1 ) are reported and discussed in this publication