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The NTS itself contains GLP-1 producing neurons which signal to decrease food-based reward in the mesolimbic VTA and NAc, which in turn impact memory and emotional processing in the hippocampus and amygdala [40]

Most gastrointestinal side effects such as bloating and gas are mild and self-limiting, typically resolving within days to weeks as the gut microbiome adjusts to the introduced bacterial strains

34 In the double-blind study, seven patients received subcutaneous exenatide twice daily and eight patients received placebo